Principal Scientist, Translational Research

Lab Based – San Diego, CA

About IconOVir

IconOVir Bio is a preclinical-stage biotechnology company pioneering the next generation of oncolytic virus therapy to improve the treatment of patients with cancer. The Company’s proprietary oncolytic virus platform is based on technology developed by scientific founder Clodagh O’Shea, Ph.D., of the Salk Institute. It is designed to address key limitations of first- and second-generation oncolytic viruses and provide a personalized therapy for cancer patients.

Summary of Position

We are seeking a Translational Scientist to assist with IconOVir’s discovery and development efforts. Reporting to the Head of Translational Research, the successful candidate will be responsible for identifying and progressing new product opportunities from analysis of drug projects to developing and leading pre-clinical and clinical validation project plans, and will influence strategic direction based on new core science and/or disease opportunities.

Essential Duties and Responsibilities

  • Initiate and lead projects by managing overall process, data analysis, risk mitigation and decision-making required to progress projects from pre-clinical to early clinical development, and apply expertise to influence overall translational research strategy and project progression
  • Formulate biomarker strategies in collaboration with internal program teams
  • Collaborate with, and manage, CROs to identify predictive biomarkers with an emphasis on the development and validation of pharmacodynamic assays to support pre-clinical studies
  • Lead the development and implementation of the biomarker plans for clinical studies
  • Contribute to regulatory documents summarizing translational strategy
  • Maintain appropriate documentation and audit trail
  • Communicate scientific progress to company leadership and key stakeholders

Qualifications

  • Ph.D. with at least 6 years of industry experience in drug discovery and translational research
  • Proven experience with development of predictive biomarkers
  • Experience in managing CROs, and working with Central Labs for shipping and logistics
  • Oncology and/or immunology knowledge is highly preferred
  • Experience in designing and conducting in vivo experiments in preclinical models and working knowledge of ex vivo assays, such as NGS, flow cytometry, IHC
  • Perform standard molecular biology techniques (e.g. Western blot analyses, ELISAs, quantitative PCR, etc.) when needed
  • Experience in preparing documents/reports/submissions for regulatory agencies and maintaining audit trail, along with previous interactions with regulatory authorities and preparing to file for phase II and III
  • Must have strong interpersonal skills, effective communication, and demonstrated ability to work well and influence across functional teams

Disclaimer

The above statements are intended to describe the general nature and level of work being performed by employees assigned to this classification. They are not intended to be construed as an exhaustive list of all responsibilities, duties and skills required of employees assigned to this position.

IconOVir is an equal opportunity employer.  We celebrate diversity and are committed to creating an inclusive environment for all employees.

IconOVir does not discriminate in employment on the basis of race, color, religion, sex (including pregnancy and gender identity), national origin, sexual orientation, marital status, disability, genetic information, age, parental status, military service, or other non-merit factor or other prohibited grounds specified in applicable federal, state and local laws.

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